Archive for the ‘ucla’ Category

New Orleans Reloaded

Tuesday, November 18th, 2003

A few interesting things I noticed while organizing my photo album:

1. The pictures below present a similar scenario. Brian/Josh is brandishing his mysterious stick next to Ashley’s bed as I prepare to guard against one of many vicious blows. What I can’t seem to figure out is why Brian/Josh is wearing a different outfit in each picture.

2. Below we have The Pointless Item of the Day: The SFN conference itinerary

3. Whether a film or speech or picture or song, every great piece of art can be defined by one lasting image, one trait that symbolizes its very essence. For Team Neuroscience, the one item that represents our time in New Orleans is the one pictured below. Here, we see Brian/Josh (where Josh >> Brian) slamming a handful of turkey into Seth’s mouth while Mike looks on in horror. Mike’s expression: quite possibly the funniest thing I have ever seen.

* Movie Quote of the Day: “More!”

La Nouvelle Orleans

Monday, November 17th, 2003

Accessing the Internet wasn’t as easy as the Society for Neuroscience had promised, so my official New Orleans recap is coming at end of the experience as opposed to the periodic updates that I had hoped to make. I apologize for this delay, but only out of formality, as I am the poor soul who is being forced to write these journal entries. Off we go,..

Last week started with the potential to be an incredible week in my life. My couch was delivered on Tuesday, Team Neuroscience saw The Matrix Revolutions at the IMAX on Wednesday, and then it was off to New Orleans for a week of Bourbon St. fun interrupted by the occasional poster presentation. I’m going to save the more restless of you the trouble and cut right to the chase: New Orleans exceeded all of our expectations and our trip ended up being an incredible bonding experience.

Jen B.’s decision to rent a house just outside the French Quarter may have been the most important part of the New Orleans experience. In fact, if I weren’t fundamentally opposed to the “shout out”, I would most certainly give a “shout out” to Jen followed immediately by a standard “holla!”. While not located directly on Bourbon St., our house was close enough to ensure regular sightings of New Orleans’ finest weirdos yet far enough removed to avoid the mind-numbing stench that saturates the area. I was particularly satisfied with our location when Ashley described the origins of that unmistakable Bourbon St. stench so strong it burns your nostrils as you breath: the combined effect of hundreds of years of feces, urine, beer, vomit, and garbage pooling against the street gutters. Yum. Anyway, our house at 1918 Burgundy St., (pronounced Bur-GUN-dee) had a kitchen, backyard, a parlor, and enough room to sleep a dozen people “comfortably”. The group included the usual cast of characters: Ashley nabbed the most comfortable bed in the house, Deb and Seth all but colonized the downstairs bed, Libby and Mike were keen on the air-mattresses, Jen chose the upstairs full, I opted for the couch, and Brian/Josh pretty much slept wherever.

The instant we arrived in our neighbourhood, we spotted a 24-hour bar named “Iggy’s”, which proved to be a sort of safe-haven, before and after our nightly adventures through the French Quarter. The bartender, Liz, quickly became our best friend in the entire world. A New Orleans native, Liz was full of interesting stories of the culture and history of her hometown. Right down the road was my personal favorite, the Praline Connection, a soul food restaurant introduced to us by Seth. I could have eaten at this place three or four times a day if it was practical. In fact, if it was up to Libby and I, we would have spent the entire conference hanging out at Iggy’s and the Praline Connection all hours of the day. This was unlikely to occur, however, due to the obvious safety issues in our area. The lack of safety became painfully clear to me when I noticed the “obstacles” mounted on some of the local residents’ fences to keep intruders away(below). Yikes.

Here is a randomly assorted list of items that will likely be meaningless unless you just so happened to be in New Orleans with us this week:

Brian/Josh and his sticks

UHF

Turkey in Seth’s mouth

Mike’s Face (T-shirts)

“I eventually got wet in the shower, though it’s unclear how.” – Seth B.

Santorum

The howling wolf

Ashley’s Beans and Rice

Mike’s headrest

86′d

Seth’s transformation from “The Human Missile” into “The Human Bomb”

Someone sleeping in the house at all times

Seth and John fencing

Librium, the Liberator, The Libyans!, MadLibs

“It’s unclear.” – Seth B.

Hurricanes

Swan-shaped Doggy Bags

Deborah’s late night Po’ Boy deliveries

“I don’t think I’m going to the conference today.” – Everyone

Mark’s tour of the house

Floyd getting butt-hurt about his inadequate tip

Patty O’Brien’s aka Carlos O’Brien’s aka Mohammed O’Brien’s

The Dragon’s Den

Seth getting carded

The Adulterer

The really high shower head and the really low bathroom sinks

That song that some random girl sang outside Iggy’s

The grocery list

the John

Seth talking to his clone

Brian/Josh’s orange shirt

Indeed, just about everything that needed to happen in New Orleans did:

Brian/Josh was in top form throughout the week.

In a surprising turn of events, I managed to go the entire week without being stanked.

Ashley reconnected with her Louisianan roots, as evidenced by the emergence of her southern drawl and the constant stream of “y’alls” echoing throughout the house.

Libby, Brian/Josh, and I were lucky enough to spot the Pink Panther in all his tight-jeaned glory.

Jen B.’s talk went very smoothly despite only three hours of sleep, that darned elusive cup of coffee, and some unruly woman from U Penn that tried to sabotage Mark’s laptop.

I saw more weird people during one walk through Bourbon St. than I have seen in a year in Los Angeles.

Some random girl on Seth’s flight home referred to our place as “The Party House”, confirming that we had indeed accomplished our goal.

In retrospect, I can’t claim to have learned anything neuroscience-related from my week in New Orleans. I read countless posters, I went to a bunch of talks, and I even toured the biotech vending area, but ultimately, I just ended up having a lot of fun. Too much fun. An inordinate amount of fun. So much fun, in fact, that it’s difficult for me to articulate on this journal exactly how much fun was had. This is why we collectively documented much of our experience digital cameras. I’ll be posting these pictures tomorrow for the entire world to enjoy.

* Libby O.Quote of the Day: “You missed Brian/Josh in top form last night!”

* Jen B. Quote of the Day: “You missed Brian/Josh in top form last night!”

* Seth B. Quote of the Day: “You missed Brian/Josh in top form last night!”

* Brian/Josh Quote of the Day: “I have no idea what happened last night.”

* Movie Quote of the Day: “Everything that has a beginning has an end.”

Halloween Pictures Reloaded and The Matrix Revolutions: Prologue

Tuesday, November 4th, 2003

The picture below confirms a previous story of mine regarding a city bus smashing into Ashwini’s apartment, which if you’ll recall, was just about the most ridiculous thing I had ever seen in my entire life at that point. That is, until this afternoon, when I got myself involved in a live journal dialogue that has now replaced the aforementioned bus incident as the most ridiculous item in my entire life. Click here to remind yourself about the bus incident.

I just got done watching The Matrix Reloaded with Pejman, Richard and Joy, though I’m reluctantly including Joy because she fell asleep one minute into the movie. There are two interesting things to note here. One is that anyone who didn’t like The Matrix Reloaded needs a nice talking to. Second, The Matrix Revolutions opens tomorrow and I’m giddy as hell. I’m getting all anxious and jittery, just like I used to get on Christmas Eve. You remember that feeling–you’re so incredibly excited and at the same time worried that you won’t get exactly what you wanted. Of course, I never really had to worry about that as a child. Marty always knew which “Nintendos” to get me and Marygrace is always good for a Maya Angelo poetry book or tickets to a cultural event. It was poor Lindsay who always got stiffed. The look on Linds’ face when she opened those presents is priceless. Well, I’m babbling…let’s save that line of discussion for another journal entry.

I’m seeing The Matrix Revolutions with just about everyone in my Neuroscience class plus Pejman, Richard, and Jen C., so I anticipate a good time whether or not the movie pays off. Note, however, that you will all die if the latter scenario takes place.

* Richard Stranded in Los Angeles Update of the Day: 12 days and counting

* Movie Quote of the Day: “It’s the smell!”

Halloween Medical Style

Sunday, November 2nd, 2003

Many of you are now familiar with the Brian/Josh Duel-Identity Syndrome (DIS) that from time to time transforms our happy-go-lucky Brian into the self-proclaimed “Evil Stanking King of Steel Town”. I am embarrassed to admit that I, too, am plagued by this terrible disease though to a much lesser degree than our dear Brian/Josh. Indeed, my alter-ego surfaces and tends to control my every move, but unlike Brian/Josh, I am able to decide when and where my transformations take place. And so, it has been decided that Wally will inhabit my body on the one day of the year that belligerence, rowdiness, and general offensive behavior is permitted: Halloween.

You might remember Wally from such Halloween disasters as Halloween 2000 in Isla Vista (pictured above with Hasmeek). This year, Wally and his cronies (pictured below) opted to join the UCLA Medical students at their annual Halloween charity event. As can be assumed from his stunning corduroy jacket, stylish clip-on tie, and fresh perm, Wally has clearly matured since his last Halloween adventure. The rest of the gang included Pejman dressed as not-so-famous professional boxer Zab Judah; Richard as “Evil” Davy Crockett; and Ashwini as herself wearing giant butterfly wings. We headed to the party Friday night–late enough for the med students to finish their daily 5 hours of studying–and met up with a group of Ashwini’s first-year friends.

Two Michael Jackson songs started the party right, giving Wally an opportunity to immediately humiliate himself in front of Ashwini’s peers, and this was followed by 100 consecutive hip hop songs that my body is completely incapable of dancing to. Which meant for the next three hours Wally simply gyrated uncontrollably as a substitute for actually dancing. I was ashamed, yes, but this shame was certainly shared by a variety of characters at the party including “No Face”, Humpty Dumpty, the guy dressed as Eminem, and the girl wearing nothing but a black-laced teddy. And, of course, there was Richard walking up to random women saying, “Excuse me, can I AXE you a question?”. Get it? Cause he’s holding an axe. Yeah, I didn’t get it either. Anyway, we all had a lot of fun meeting Ashwini friends and finally getting to see who she spends inordinate amounts of time with in the Graduate Reading rooms atop the Biomed Library. I would have liked to meet them on different circumstances, though I suppose I could have been one of their patients with a bad case of rickets. You never know.

* Ridiculous Item of the Day: Minnesota Vikings player insulting the Green Bay Packers green and yellow uniforms by saying, “Purple and yellow is a much better color.”

* Movie Quote of the Day: “I know Kung Fu.”

Boozefest 2003: A Tribute

Tuesday, October 28th, 2003

The Annual Neuroscience BoozeFest (a.k.a The Neuroscience Retreat) took place last weekend in Laguna Beach, and just as anticipated, BoozeFest 2003 was definitely good for a few memories. We immediately broke our traditional driving arrangements when Brian/Josh drove in my place, but this gave me the perfect opportunity to get a few pictures from the car. Take, for instance, this stunning snapshot of the famed “Pollution Factory” just outside of Long Beach. That’s right: a pollution factory. A factory that produces pollution. Here, pollution is not a byproduct but THE product. I guess it fits perfectly if you’re going for that “industrialized” style of architecture, but otherwise, the concept doesn’t make much sense to me. And, throwing the American flag up for aesthetics is really just about the most awful thing I’ve ever seen.

Anyhow, the rest of our drive went without incident–though Seth’s confusion regarding cyclists’ advertisement-laden spandex and our general amusement by the Laguna Beach “Dog Park” is worth mentioning–and we arrived just in time for the world famous Aliso Creek bacon and egg breakfast. Only, this year, there was no bacon. Admittedly, we were all very disappointed, and were it not for a surprise appearance by “The Honeybee and his henchman”, we would have been in a horrible mood to start things off. After breakfast sans bacon, it was into the conference room for a virtually unintelligible, yet somehow interesting talk by the keynote speaker, as well as several student talks. I was most excited to learn some of what my fellow first-year (now second year!) students are accomplishing in their graduate work and to see them speak coherently and with such enthusiasm about their findings (see, Jen and Stephen’s talks).
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After lunch, more talks, dinner, and about 20 “coffee breaks”, the evening activities began with a costume competition and a happy fun Vegas theme party. What could be better than a bunch of stressed out Neuroscientists drinking and gambling away all of their pent up angst while dressed as their favorite cartoon characters from their youth? Of course, it is important to note that the gambling was with fake money and the costume “competition” was more on the NOT competitive side given that Fred was one only of two people wearing a costume (see picture below). Still, he deserves a lot of credit for showing up in that outfit and prancing around posing for pictures with everyone the entire night.

It’s sad to hear that this year’s BoozeFest might be the last of its kind. I had a wonderful time hanging out with everyone in the program, and it was great to see Jen and Stephen get such an enthusiastic response from audience during their talks. Is it wrong to not be excited about next year’s Saturday “retreat” in the first floor Gonda conference room?

* Josh J. Quote of the Day: “How do we get back to the brownies?”

* Josh J. Quote of the Day: “Are you the Tenia?”

* Josh J. Quote of the Day: “ConractandriphoutgoddamSPINE!! Whyyyyyyyyyyyyyyyyyyyyy!?”

* Jen B. Quote of the Day: “I’d rather sit in back so I don’t have to see what Brian is doing.”

* Seth B. Quote of the Day: “What are the talking about? Do we really have to sit hear and watch this?”

* Gene G. of the Day: “The chair is perfect!”

* Seth B. Quote of the Day: “Hey, Blue Dot! Get me some coffee!”

* John Ohab Quote of the Day: “I can’t take another one of your thrashings!”

* Movie Quote of the Day: “You stole it! He stole it!”

I’ve got your qualification right here!

Friday, September 12th, 2003

I just wanted to thank a few people who helped get me through the written qualifying exam experience:

Deborah: Thank you for bringing the inordinate amounts of junk food that kept me “energized” and “focused” during our journal clubs.

Libby: Thank you for coordinating the journal clubs and keeping everyone accountable for reading and presenting their papers. Also, sorry about the “Woopsy!” section.

Seth: Thank you for FACSing everything.

Thao: Thank you for the Harley Kornblum pep talk Friday morning.

Brian: Thank you for all of our power study sessions that consisted of us meeting in your “lab”, reading ESPN.com, checking our fantasy football statistics, going to InNOut for lunch, reading one or two figures of a paper, checking our fantasy football statistics, and then getting bored and going home for the night.

Nathan: Thank you for your love and kindness.

Suzie: Thank you for putting everything in perspective whenever I talk to you.

Jen B:

  • Thank
    • you
      • for
        • your
          • review
            • sheets!

    And, now, the official list of papers… I know they each hold a special significant in our lives. How can we forget Pax6 or Olig1 or the MEK/ERK/RSK1/C/EBP pathway? Over the past month, these papers have grown to be a part of us. Cherish their memories always…

    Permeation and Gating Residues in Serotonin Transporter

    Sodium-Dependent Norepinephrine-Induced Currents in Norephinephrine-Transporter-Tranfected HEK-293 Cells Blocked by Cocaine and Antidepressants

    Mutation of an Amino Acid Residue Influencing Potassium Coupling in the Glutamate Transporter GLT-1 Induces Obligate Exchange*

    Neurotransmitter transport: Models in flux

    Characterization of a Functional Bacterial Homologue of Sodium-dependent Neurotransmitter Transporters*

    Steady States, Charge Movements, and Rates for a Cloned GABA Transporter Expressed in Xenopus Oocytes

    Glial Cells Generate Neurons: the Role of the Transcription Factor Pax6

    Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

    An Essential Role for a MEK-C/EBP Pathway during Growth Factor-Regulated Cortical Neurogenesis

    Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

    Progenitor Cell Maintenance Requires Numb and Numblike During Mouse Neurogenesis

    Timing of CNS Cell Generation: A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells

    Neurogenin Promotes Neurogenesis and Inhibits Glial Differentiation by Independent Mechanisms

    A PDGF-Regulated Immediate Early Gene Response Initiates Neuronal Differentiation in Ventricular Zone Progenitor Cells

    Direct Neural Fate Specification from Embryonic Stem Cells: A Primitive Mammalian Neural Stem Cell Stage Acquired through a Default Mechanism

    A Model for the Coupling Between Cerebral Blood Flow and Oxygen Metabolism During Neural Stimulation

    Dynamics of Blood Flow and Oxygenation Changes During Brain Activation: The Balloon Model

    Temporal Spatial Differences Observed by Functional MRI and Human Intraoperative Optical Imaging

    Human Hippocampal Long-term Sustained Response During Word Memory Processing

    Very Slow Activity Fluctuations in Monkey Visual Cortex: Implications for Functional Brain Imaging

    Four facets of a single brain: behaviour, cerebral blood flow/metabolism, neuronal activity and neurotransmitter dynamics

    Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation

    An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds

    Sustained Negative BOLD, Blood Flow and Oxygen Consumption Response and Its Coupling to the Positive Response in the Human Brain

    Cellular Mechanisms of Brain Energy Metabolism and Their Relevance to Functional Brian Imaging

    Dynamic Uncoupling and Recoupling of Perfusion and Oxidative Metabolism during Focal Brain Activation in Man

    BOLD Based Functional MRI at 4 Tesla Includes a Capillary Bed Contribution: Echo-Planar Imaging Correlates with Pervious Optical Imagine Using Intrinsic Signals

    Metabolic Anatomy of Brain: A Comparison of Regional Capillary Density, Glucose Metabolism, and Enzyme Activities

    Neurophysiological Investigation of the Basis of the fMRI Signal

    * Brian/Josh Quote of the Day: “I haven’t even printed out half of the papers yet.”

    * Brian/Josh Quote of the Day: “I’m not going to read the rest of the systems papers. I mean, come on, I know what BOLD is.”

    * Seth B. Quote of the Day: “I heard that you had to FACS something at least three times during your exam to pass.”

    * Seth B. Quote of the Day: “I plan to score a High Pass with Honors Work.”

    * Movie Quote of the Day: “Easy, miss. I’ve got you.”

    Qualify THIS!

    Friday, September 12th, 2003

    Get ready world because I have escaped the Black Hole of Studying (that’s just the name I gave it) and am returning to the real world! Yep, this is a pretty big moment for me and the rest of the Neuro-crew. We are officially done with the Written Qualifying Exam!!! (unless, of course, we fail it and have to retake it).

    Taking the written qualifying exam itself didn’t turn out to be the worst experience of my life (that honor undoubtedly goes to the fall quarter Neurophysiology exam). In fact, the worst part of the experience wasn’t having to read 40 papers or having to balance a heavy research load or even trying to comprehend the figures in that silly GABA Transporter paper. It was simply the inevitability of the exam. The stress of waiting and worrying and wondering what exactly we were going to be tested on.

    This is not to say that the exam went smoothly and that I feel super confident about my answers. One of the problems with these kinds of exams is that there is really no way to feel good about things when you’re finished. It’s not like a multiple choice or short answer exam, where there is a finite amount of knowledge and once you account for that, there is nothing left. Instead, we are basically given open questions with no limits or constraints, and expected to generate comprehensive and coherent answers. It’s really quite daunting when most of us have never been directly exposed to the material we’re being tested on. It’s funny how I was the “expert” in our group because I happen to be in a lab that does molecular biology. Never mind that I just joined the lab two months ago and that I have never once done any of the techniques covered during the exam. I guess I can’t complain given the expectations that come along with the perks of being a self-proclaimed genius.

    There will be more reflections on my qualifying exam experience, but first I am going to enjoy my freedom. And, by “enjoy”, I mean “watch TV”.

    Here is a funny exchange that took place yesterday during our break between the cellular and systems exams:

    Jen B: I’m feeling pretty confident about the cellular portion of the exam.
    Seth: Yeah, that’s because it’s in the past.

    * John Ohab Quote of the Day: “I’m aiming for remedial work.”

    * Seth B. Quote of the Day: “I’m already getting started on my remedial work.”

    * Brian/Josh J. Quote of the Day: “If I don’t get assigned remedial work on at least one of the sections, then I will have been studying WAY too hard.”

    * Jill D. Quote of the Day: “Traveling when you’re knocked up is not a picnic in your pants, I’ll tell you that much…”

    * Movie Quote of the Day: “He’ll live.”

    Way to go Brian!

    Thursday, August 21st, 2003

    I know I promised to continue my Grandmar story after the exciting cliffhanger ending, but I’m going to be out of town this weekend and don’t have the time tonight. I’ll be traveling to Pittsburgh on Friday with Seth B. and Jen B. to attend the “legal union” of Brian/Josh and Kathy M. If you are not familiar with Brian/Josh and his bizarre love for methamphetamine addicts and their prepulse inhibition-related problems, check out his live journal or his seldom updated website. Also, if you are interesting in knowing a bit about the wedding, namely how to buy them gifts, then feel free to visit their Official Wedding Webpage.

    Seth, Jen, and I have been looking forward to this wedding for quite some time, so the expectations are extremely high. Brian/Josh has promised us several different versions of the Family Robot Dance. This has the make-up for an exciting weekend in the beautiful August weather of Pittsburgh. There will be much to talk about when I return, so stay tuned…

    * Brian/Josh Quote of the Day: “Hey, John, remember that one Seinfeld episode when George gets upset about something and then Jerry makes a sarcastic comment? That was hilarious.”

    * Movie Quote of the Day: “Got to catch the Red Eye!”

    Not Concerning Grandmar But Still A Fabulous Journal Entry In It’s Own Special Way

    Tuesday, August 19th, 2003

    A few silly items from today:

    • Libby: Did you hear about that guy who was decapitated by the elevator?
      Emily: No, I missed that headline.
    • As we walk into Starbucks, Joy proclaiming “I think I’m going to buy some coffee!”.
    • A random lab story: A few of the researchers in our lab were chatting one day, when Jeff, an MD-PhD student, claimed to have used the rodent rectal probe to measure his temperature. He said he was feeling ill and figured the rectal probe would be as accurate as any thermometer. Of course, he was 100% joking. Unfortunately, another MD student rotating in our lab didn’t catch on to the joke. A few weeks later, she started feeling warm, and proceeded to wipe the rectal probe with alcohol and measure her temperature through her ear. Were it not for the unspeakable horrors that I perform everyday in the name of science, this incident would be one of the more disgusting things I’ve ever heard.
    • Somebody signed my guestbook under the name “Frank the Frankenstein Foreskin” with the following message (which will never be posted because this anonymous person has no brain):
      “He he. John and I go way back. We used to be naked models together for some art people round town. Then our lives came to a crossroads. John made up his silly little mind to become a neuroscientist while I decided to fulfill my dream of becoming a sex actor. We were great together John my man! They didn’t call you John the Bomber for nothin’!”

    • A portion of the mural outside the elevator on my floor. My question: What could possibly be going on behind the scene that is producing this man’s facial expression?

    * Movie Quote of the Day: “I’m dancing…”

    Ceremonies

    Sunday, August 10th, 2003

    It’s that time of year again when people are being recognized for their accomplishments.

    First and foremost, I’d like to recognize me. Thank you.

    Last Thursday, Joy was honored along with her fellow Teach for America colleagues for the completion of the teacher certification program. After a rigorous summer program, Joy and her fellow teachers now return to schools in underprivileged areas across the country to provide quality education to hundreds of thousands of children. Joy will be teaching chemistry at Crenshaw High, about 10 miles south of where we’re living in West LA. Quickly, I wanted to apologize for giving everyone the wrong phone number to our apartment. I blame everything on Devon. Just like when she broke the ice machine. Thanks a lot, Devon.

    On Friday, I was lucky enough to have some free time during my 10 straight hours of cryostat work, so I took a short (25 minute) walk to the opposite side of campus to attend Ashwini’s White Coat Ceremony. The White Coat Ceremony, for those who aren’t doctors (really, who isn’t!?), is the initial “welcome” into the medical program, where students accept the responsibility of being a health care provider, both symbolically and literally, when they physically put on the white coat. Having trouble visualizing this concept? Check out these secret snapshots of Ashwini in action:

    Congratulations!!!!

    * Exciting News of the Day: The message I received regarding my application for Fall 2003 Parking at UCLA: “We are pleased to offer you 2-Person Carpool parking in LOT 8. The per person cost for a 2-Person Carpool is $73.5/quarter”

    * Movie Quote of the Day: “That would be me. I’ve been swimming in raw sewage. I love it.”